Nuclear reprogramming to a pluripotent state by three approaches
نویسندگان
چکیده
منابع مشابه
Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming
During embryonic development pluripotency is progressively lost irreversibly by cell division, differentiation, migration and organ formation. Terminally differentiated cells do not generate other kinds of cells. Pluripotent stem cells are a great source of varying cell types that are used for tissue regeneration or repair of damaged tissue. The pluripotent stem cells can be derived from inner ...
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Induced pluripotent stem cells (iPSCs) are generated from somatic cells by the transduction of defined transcription factors, and this process involves dynamic changes in DNA methylation. While the reprogramming of somatic cells is accompanied by demethylation of pluripotency genes, the functional importance of de novo DNA methylation has not been clarified. Here, using loss-of-function studies...
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Life on Earth is constantly exposed to natural electromagnetic fields (EMFs), and it is generally accepted that EMFs may exert a variety of effects on biological systems. Particularly, extremely low-frequency electromagnetic fields (EL-EMFs) affect biological processes such as cell development and differentiation; however, the fundamental mechanisms by which EMFs influence these processes remai...
متن کاملnetwork analysis of transcription factors for nuclear reprogramming into induced pluripotent stem cell using bioinformatics
objective: research related to induce pluripotent stem (ips) cell generation has increased rapidly in recent years. six transcription factors, namely oct4, sox2, c-myc, klf4, nanog, and lin28 have been widely used for ips cell generation. as there is a lack of data on intra- and inter-networking among these six different transcription factors, the objective of this study is to analyze the intra...
متن کاملI-12: Nuclear Reprogramming in Bovin Somatic Cell Nuclear Transfer
Somatic cell nuclear transfer (SCNT or cloning) returns a differentiated cell to a totipotent status; a process termed nuclear reprogramming. Reproductive cloning has potential applications in both agriculture and biomedicine, but is limited by low efficiency. To understand the deficiencies of nuclear reprogramming, our research has focused on both candidate genes and global gene expression pat...
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ژورنال
عنوان ژورنال: Nature
سال: 2010
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature09229